Suppression of cancer stemness by upregulating Ligand-of-Numb protein X1 in colorectal carcinoma.
Cancer stem-like cells (CSCs) have been reported to play major roles in tumorigenesis, tumor relapse, and metastasis after therapy against colorectal carcinoma (CRC).Therefore, identification of colorectal CSC regulators could provide promising targets for CRC.Ligand-of-Numb protein X1 (LNX1) is one E3 ubiquitin ligase which mediates the ubiquitina